Cyclin B

cyclin B1
Identifiers
Symbol CCNB1
Alt. symbols CCNB
Entrez 891
HUGO 1579
OMIM 123836
RefSeq NM_031966
UniProt P14635
Other data
Locus Chr. 5 q12
cyclin B2
Identifiers
Symbol CCNB2
Entrez 9133
HUGO 1580
OMIM 602755
RefSeq NM_004701
UniProt O95067
Other data
Locus Chr. 15 q21.3
cyclin B3
Identifiers
Symbol CCNB3
Entrez 85417
HUGO 18709
OMIM 300456
RefSeq NM_033670
UniProt Q8WWL7
Other data
Locus Chr. X p11

Cyclin B is a member of the cyclin family.

Cyclin B is a mitotic cyclin. The amount of cyclin B (which binds to Cdk1) and the activity of the cyclin B-Cdk complex rise through the cell cycle[2] until mitosis, where they fall abruptly due to degradation of cyclin B (Cdk1 is constitutively present).[3] The complex of Cdk and cyclin B is called maturation promoting factor or mitosis promoting factor (MPF).

See also

References

  1. ^ Petri, E.T., Errico, A., Escobedo, L., Hunt, T., and Basavappa, R. (2007). "The crystal structure of human cyclin B". Cell Cycle 11 (11): 1342–9. PMID 17495533. 
  2. ^ Ito M (August 2000). "Factors controlling cyclin B expression". Plant Mol. Biol. 43 (5-6): 677–90. doi:10.1023/A:1006336005587. PMID 11089869. http://www.kluweronline.com/art.pdf?issn=0167-4412&volume=43&page=677. 
  3. ^ Hershko A (September 1999). "Mechanisms and regulation of the degradation of cyclin B". Philos. Trans. R. Soc. Lond., B, Biol. Sci. 354 (1389): 1571–5; discussion 1575–6. doi:10.1098/rstb.1999.0500. PMC 1692665. PMID 10582242. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1692665. 

External links

Cyclin
A (A1, A2) · B (B1, B2, B3) · D (D1, D2, D3) · E (E1, E2)
CDK
2 · 3 · 4 · 5 · 6 · 7 · 8 · 9 · 10 · CDK-activating kinase
CDK inhibitor
P53 p63 p73 family
p53 · p63 · p73
Phases and
checkpoints
Other cellular phases
B bsyn: dna (repl, cycl, reco, repr) · tscr (fact, tcrg, nucl, rnat, rept, ptts) · tltn (risu, pttl, nexn) · dnab, rnab/runp · stru (domn, 1°, 2°, 3°, 4°)